Sites like this one were really popular a few years ago, but I’ve never seen one executed this well. The faux-desktop interface is an interesting demonstration of the individual’s web design skills. The risk with doing a site like this one is that you might lose the focus on the site’s real purpose. And it might be less intuitive and easy to use than a “normal” —but in this site’s case, I think that’s part of the point. Its unique nature is what makes it so darn special.
Need more design inspiration? Check out the Web Designer’s Idea App for iPad, with hundreds of stellar websites selected by Patrick McNeil.