I seem to be on a roll lately with the experimental layouts. This site’s unusual layout just requires you to scroll (though there are also a hidden menu on the left and up/down buttons). Although the content doesn’t follow any standard layout, the interface is pretty obvious and easy to use. I love the attention paid to the custom layout and color palette for each set of content.
Need more design inspiration? Check out the Web Designer’s Idea App for iPad, with hundreds of stellar websites selected by Patrick McNeil.